Susan Tyrrell, nascuda Susan Jillian Creamer (San Francisco, Califòrnia, 18 de març de 1945 - Austin, Texas, 16 de juny de 2012), va ser una actriu de personatges nord-americana. La seva carrera va començar al teatre a la ciutat de Nova York a la dècada de 1960 a Broadway.

Susan Tyrrell (born Susan Jillian Creamer; March 18, 1945 – June 16, 2012) was an American character actress. Tyrrell's career began in theater in New York City in the 1960s in Broadway and off Broadway productions. Her first film was Shoot Out (1971). She was nominated for the Academy Award for Best Supporting Actress for her performance as Oma in John Huston's Fat City (1972).

In 1978, Tyrrell received the Saturn Award for Best Supporting Actress for her performance in Andy Warhol's Bad (1977). Her New York Times obituary described her as "a whiskey-voiced character actress (with) talent for playing the downtrodden, outré, and grotesque."