David McCallum is best known for his role as Illya Kuryakin on the NBC TV show "The Man from U.N.C.L.E. (1964-1968)" and in the movies "To Trap a Spy (1964)", "The Spy with My Face (1965)", "One Spy Too Many (1966)", "The Spy in the Green Hat (1966)", "One of Our Spies Is Missing (1966)", "The Karate Killers (1967)", "The Helicopter Spies (1968)", "How to Steal the World (1968)" and "The Return of the Man from U.N.C.L.E.: The Fifteen Years Later Affair (1983)", and as Dr. Donald "Ducky" Mallard on the CBS TV show "NCIS (2003-2023)".

He played Simon Carter on the BBC TV show "Colditz (1972-1974)", Daniel Westin on the NBC TV show "The Invisible Man (1975-1976)" and Steel on the ITV TV science fiction show "Sapphire & Steel (1979-1982)".

Some other TV shows he appeared on are "The Rose and the Ring", "As the World Turns", "Our Mutual Friend", "The Eustace Diamonds", "Knight Errant Limited", "Emma", "Sir Francis Drake", "Perry Mason", "The GReat Adventure", "The Outer Limits", "Profiles in Cpourage", "Please Don't Eat the Daisies", "Night Gallery", "Marcus Welby, M.D.", "Bert D'Angelo/Superstar", "Kidnapped", "Strike Force", "Hart to Hart", "The Master", "The A-Team", "Matlock", "Monsters", "Mother Love", "Lucky Chances", "Father Dowling Mysteries", "Murder, She Wrote", "Boon", "Cluedo", "Trainer", "SeaQuest 2032", "Babylon 5", "Scavengers", "Heartbeat", "Mr. & Mrs. Smith", "VR.5", "Law & Order", "Three", "Coming Home", "Team Knight Rider", "Sex and the City", "Deadline", "The Education of Max Bickford", "Jeremiah", "JAG" and "NCIS: New Orleans".

He played Lieutenant Commander Eric Ashley-Pitt, "Dispersal" in the movie "The Great Escape (1963)" and Judas Iscariot in "The Greatest Story Ever Told (1965)".

Some other movies he appeared in are "The Secret Place (1957)", "Hell Drivers (1957)", "Robbery Under Arms (1957)", "Violent Playground (1958)", "A Night to Remember (1958)", "Antigone (1959)", "Jungle Street Girls (1960)", "Jungle Figters (1961)", "Karolina Rijecka (1961)", "Wuthering Heights (1962)", "Billy Bud (1962)", "Freud (1962)", "The Unknown (1964)", "Around the World Under the Sea (1966)", "Three Bites of the Apple (1967)", "Sol Madrid (1968)", "Teacher, Teacher (1969)", "Mosquito Squadron (1969)", "La cattura (1969)", "The File on Devlin (1969)", "Hauser's Memory (1970)", "She Waits (1972)", "The Six Million Dollar Man: Wine, Women and War (1973)", "Frankenstein: The True Story (1973)", "Screaming Skull (1973)", "The Kingfisher Caper (1975)", "Dogs (1976)", "King Solomon's Treasure (1979)", "The Watcher in the Woods (1980)", "Terminal Choice (1985)", "Behind Enemy Lines (1985)", "The Wind (1986)", "Az aranyifjú (1986)", "Freedom Fighter (1988)", "The Man Who Lived at the Ritz (1989)", "The Return of Sam McCloud (1989)", "The Haunting of Morella (1990)", "Hear My Song (1991)", "Dirty Weekend (1993)", "Fatal Inheritance (1993)", "Shattered Image (1994)", "Healer (1994)" and "Cherry ( 1999)".