Hesam Dehghani was born on September 17, 1977 in Tehran, as the first child of a physics teacher father and a history teacher mother. As a young boy, he became intrigued with playing the violin.

He attended Iran University of Science and Technology in 1995 and studied computer engineering. He made his first student short film, The Incredible Story of the Computer Campus (2000) for the university's Film Center. As a student, he directed 3 more short films, which brought him to the attention of Iran's National TV Organization. He was invited to join The Virtual Studio Project, one of the most important projects in IRIB. He worked both as a technical engineer and a film director.

He learned the basics of screenplay writing and film making from his neighbor Ebrahim Hatamikia. he also attended various training courses, including Techniques of Non-Linear Editing in Harris Company's head office in Bracknell, United Kingdom in 2003.

Hesam worked in various short and documentary film projects as a writer, director and producer. His movies "Train Station" (2015), Trauma" (2020) and "Lost Empire of Persia" (2022) received international awards.