Jones-Quartey created multiple Web Cartoonists' Choice Award-winning webcomic RPG World. He was also a founding member of the now-defunct "bagofchips" group, a collective of web cartoonists including Aaron Farber, Meredith Gran, Josh Mirman, and David McGuire. He is also the co-creator of the web animation series and comedy hip-hop duo nockFORCE, rapping under the stage name 'effnocka' along with audio specialist Jim Gisriel.

He also served as a storyboard supervisor and revisionist for Adventure Time and storyboard artist for Secret Mountain Fort Awesome. His first job in the business was on The Venture Bros.. He supplies the voice of Wallow in Bravest Warriors and was the supervising director and co-developer of the Cartoon Network series Steven Universe.

In 2013, Jones-Quartey's short Lakewood Plaza Turbo aired on Cartoon Network. It was the pilot for a potential show which has been pitched to Cartoon Network Studios for its shorts development program. The short has been retooled as a mobile game entitled OK K.O.! Lakewood Plaza Turbo, which was released on Cartoon Network's Anything app in February 2016. The show was greenlit as a new regular programming on March 2017, and OK K.O.! Let's Be Heroes premiered on Cartoon Network on August 1.