Gigi and Marlene, two single women both in their late 20's, work at a bio-technology company, researching and developing medicine to suppress specific genes and observe their effects on the human body. Gigi is born with the "clean-freak" gene and her obsession with keeping things tidy causes problems in her relationships. Marlene, on the other hand, is born with the "fat gene" and needs to regularly take pills to maintain her weight. Marlene panics when she learns that her "anti-fat" pills will be taken off the market. Their personal problems coincide with romantic ones. Marlene grows frustrated maintaining her long-distance relationships via the Internet, and Gigi leaves her boyfriend when she discovers he's cheating on her.

Gigi, qui change de petit ami comme de chemise, vit avec son amie, Marlène, une accroc du travail qui se languit de son petit ami travaillant à l'étranger. Toutes deux travaillent dans la biotechnologie. Elles s'occupent de l'élaboration de pilules pour s'embellir. Un jour, lorsque Gigi rencontre un homme qu'elle veut absolument séduire, elle décide de prendre des pilules non testées afin de soigner ses troubles du comportement. Malheureusement, les effets secondaires ne tarderont pas. Pendant ce temps, Marlène se fait séduire par le fils du propriétaire, Teddy.