《女人就是女人》的故事从班长赵凌风（黄家恒饰）开始，凌风学业成绩理想并且开始跟同班同学丽淇（麦咏楠饰）交往。可是，凌风却对自己的男儿身并不自在，并且渴望成为女性，对于性别认同感到困扰，并在一次到丽淇家的过程碰到她的妈妈宋紫洳（李蕙敏饰）。四十岁的紫洳跟丈夫志鸿（邓汝超饰）结婚十多年，跟丈夫与前妻所生的女儿关系良好。可是，志鸿却无意发现了紫洳是跨性别人士，无法接受现实，并令家庭濒临破裂。

Sung Chi Yu has been happily married for 10 years but has kept a secret from her husband Chi Hung and step-daughter Lai Kei: she is a transwoman. Everything falls apart when her husband discovers this secret. Meanwhile, Lai Kei develops her first emotions for love towards her male classmate Ghiu Ling Fung but he is hiding his own battle with gender identity. Since childhood, he has dared to think and behave like a girl but never dared to reveal it to his religious and conservative family who tell him to act like a man. In his teenage years he finds himself exploring the notion of love and identity with the help of an imaginary ideal feminine image named Rose. She springs from his heart and walks by his side through many hardships. Both Chi Yu and Ling Fung will have to overcome the prejudice of others to find happiness in themselves.