Herbalist Li (Chin Siu-ho) wants to lead a quiet life. Unfortunately for him, he spent twenty years at the home of Zhenzhu (Woo Heung Chun) and her father. Now that the old man has passed on, she's eager to marry Li even though he isn't remotely interested in her.

影片講述了神醫李藥師(錢小豪飾演)在遭遇師兄雷萬龍(樓南光飾演)後，被脅迫去治療感染僵屍病毒的少帥，並由此展開了一段光怪陸離的冒險，也揭開了一個塵封多年的秘密。