De zusters, Abbey, Crista, Jenny, Kenzi en Sophie doen hun uiterste best om hun patiënten de intensieve zorg te verlenen die zij nodig hebben in dit eerste deel van Big Breast Nurses.

Nurse Abbey is trying to convince Dr. Tommy Gunn to change her schedule to the day shift in more ways than one. Sergio has erectile dysfunction and Nurse Crista has some unorthodox way of "curing" his problem. Nurse Jenny is tired of Jack not cleaning and arranging the surgery equipment. Meanwhile, all Jack the orderly can do is stare at her tits. Mr. Brooks comes in for a prostate exam and gets aroused, which in turn seduces Nurse Kenzi. Jack Lawrence has been paralyzed from a car accident... Nurse Sophie Dee notices his penis is till hard during a sponge bath.