Equal parts Goodfellas and Dusk till Dawn, Sicilian Vampire tells the story of reputed mobster Sonny Traficante who was hoping to get away to the family hunt lodge for a little rest and relaxation and create some memories. Instead, what he got was a night he will never forget. Once there, Sonny is bitten by a bat released from a container of bananas they brought up to the lodge. The bat takes a vicious bite of Sonny's neck and then flies off into the night. From that moment on Sonny is entrusted with powers beyond that of any mortal - supersonic hearing, enhanced sight, and superhuman strength - even the ability to speak to the dead. Because of these heightened senses Sonny now feels a responsibility to right the wrongs in his life, and protect those he loves. At first, he resists these new found powers but in the end he welcomes his fate.

Этнический сицилиец Сантино Трафикантэ имеет определённый авторитет. Каждый месяц он со своими итальянским друзьями-гангстерами выезжает в загородный дом поиграть в карты. Во время одной такой посиделки на Сантино нападает непонятное животное и кусает его в шею. Теперь он — вампир.