In a mystical land filled with magic and monsters, eager adventurers scour a ten-floor dungeon in search of fame and fortune - if they are able to escape with their lives! But none dare set foot in the tenth floor, as a powerful foe will make sure that they never return to the light of day: the evil Werdna, a wizard who stole an amulet of immense power. Now, to aid a beautiful woman, a group of skilled warriors must descend to the tenth floor to find the woman's lost love, and to take back the amulet from the hands of evil!

Wizardry conta as aventuras de um grupo de personagens que entram numa masmorra para enfrentar um mago muito poderoso antes que este quebre o selo dos 1000 anos e assim evitem o fim do mundo. No caminho eles encontram com alguns novos amigos que têm suas próprias batalhas para resolver.