For John Cuttin it all started with the first sip of the wine of her life. A "Marzemino", a typical wine of the province of Trento, quoted by Lorenzo Da Ponte in his libretto for "Don Giovanni" by Mozart. The instant he tasted the blood-red drop of nectar John felt a sort of pleasant and mysterious explosion of the senses, and from that moment on, his nature is transformed. In just three years, from shy bank clerk and faithful husband became director, tombeur de femmes and the most revered and respected expert on wine in Italy. Just as he had predicted the enigmatic "Professor" who had convinced him to taste his first glass of wine. The only event that the "Professor" with his accent and his piercing blue eyes, had not predicted was that he would soon be charged with the murder of his wife Adele. While being put under pressure by the Commissioner Sanfelice, John is to reflect on the last three years of his life, dominated by a single and mad passion: wine.

Giovanni est l’expert en vins le plus réputé d’Italie. Il a quitté son emploi dans la banque pour se consacrer à l’art de la dégustation et de l’identification de cuvées d’exception. Jusqu’au jour où il est accusé d’avoir tué sa femme Adele et se retrouve au commissariat ; c’est là que le voile sera enfin levé sur l’énigme de sa passion démesurée pour le vin.

Giovanni Cuttin (Vincenzo Amato) è il capo redattore di una delle riviste più prestigiose del settore enologico italiano. Stimato wine-writer, Giovanni si divide tra degustazioni pubbliche, convegni e presentazioni di Vinodentro, il libro autobiografico che ha appena pubblicato. L'incontro con una misteriosa donna (Giovanna Mezzogiorno), però, lo conduce in una spirale di eventi che, attraverso un'indagine di polizia, fanno riaffiorare un enigmatico passato, fatto di trasformazioni radicali, calici di Marzemino e conti da pagare al destino.