The world of Salvador, a young and naive petty thief is changed by the arrival of his cousin Angel, an ex-convict in search of easy money, and with a hideout. Salvador gets wrapped up in Angel's twisted dealings in an attempt to escape from his suffocating family, dragging along his family and friends, in his criminal path. Where will this all lead?

Ambientada en medio de la miseria de los pobres de Ecuador, "Ratas, Ratones, Rateros" narra la historia de Salvador, un joven ladrón envuelto en una espiral de delincuencia cada vez mayor gracias a su primo Ángel, un ex-convicto.