In a small western town our hero Durango delivers his prisoner to the jailhouse and then goes to the local saloon where the lady saloon owner Joanne has eyes only for him. But Durango only has eyes for his bride-to-be Lucy. Four masked men attack Lucy's father's farm and steal Lucy's dowry. They kill Lucy and her parents after the father strips the face mask from one of the bandits. A pocket watch is stripped from one of the bandits by Lucy's father and this is the only clue that Durango will have to revenge his love... With Joanne's help can Durango avenge himself?

Vier eiskalte Banditen, denen Django (Tab Hunter) auf der Spur ist, bekommen zu spüren, dass Django schneller als der Tod ist. Sie hätten vorher wissen müssen, dass man sich nicht mit Django anlegt. Selbst eine Flucht kann ihnen nun nicht mehr helfen, denn Django vollzieht seine Rache Mann für Mann - Schuss für Schuss.

La venganza emprendida por un sheriff (llamado Durango) cuya novia ha sido asesinada cuando estaban a punto de casarse.