1889: the five remaining vampire clans in Europe are training to survive. In their midst is 14-year-old Alisa who has the power to choose between eternal life as a vampire or for all vampires to live as humans.

Sotobamura is a small village with around 1300 residents; so small the village isn't even connected to a single highway. An isolated village in which old customs, such as the burial of the dead, are still practiced. One day, the bodies of three people are found dead. Although Ozaki Toshio, the village's lone doctor, feels uncertain, he treats the deaths as a normal occurrence. However, in the days following, the villagers start to die one after the other.

Mina Tepeş, the Princess of the ancient covenant and ruler of all vampires, wants her race to stop hiding from the humans. Using her vast wealth, she has paid off Japan's entire national debt and by doing so, gained the right to create a district off Japan's coast that is to become the future haven to vampires worldwide. But when she finally attempts to make public the existence of vampires to the world some politicians, terrorists and rival factions are plotting to assassinate Mina before she has a chance to get Japan's and international recognition for the Vampire Bund. Now she must rely on her strength, cruelty and those closest to her, while trying to make a normal life.

The modern-day vampire comedy centers on high school girl Amano, who was saved from a strange incident by a vampire girl named Sophie Twilight, and has been interested in her ever since. Akari arrives at her house uninvited and the two start to live together. Although a vampire, Sophie never attacks humans, but purchases blood and anime goods via mail and lives a modern life.

The Little Vampire is a Canadian-German children's television series created in 1985 by the German Polyphon Film- und Fernsehgesellschaft and Canadian Norflicks Productions Ltd. The series is based upon the similar books written by Angela Sommer-Bodenburg.