The film tells the story of two good friends who live together, Andrew, an agoraphobic travel agent who works from his home, and Dave, a loser who works in an office where he is treated with contempt. Just when it seems things can't get any worse for the two, the entire world outside of their house disappears and is replaced with an endless white void.

Peter and Chris, two young American friends in their late 20s, go from South Dakota to California on a scooter, and as they travel across the American landscape they see their country through different eyes, ranging from Peter's cynically nihilistic point of view, to Chris' high expectations and romantic notions of the United States.