Amelie har haft en trist barndom uden kærlighed og arbejder nu som tjener. Hun har en romantisk og fantasifuld natur, og en dag beslutter hun sig for fremover at gribe ind i andre menneskers liv for at bringe lykke og glæde. De bringer hende i kontakt med en lang række mennesker, heriblandt den hypokondriske Georgette, den aldrende og skrøbelige kunstner Dufayel og den ensomme Nino, der er ekspedient i en videoforretning.
Kassie vil gerne have et barn, men der er ikke nogen mand i hendes liv. Wally vil gerne være manden i Kassie’s liv, men Kassie er ikke interesseret. Kassie beslutter at lade sig inseminere, og i en brandert sørger Wally for, at det bliver med hans sæd. Det ved Kassie ikke, og næste dag kan Wally intet huske. Men da han syv år senere møder Kassie’s søn, er der et eller andet ved knægten, der virker bekendt.
Skye, en kæk teenager med en dødelig sygdom, og Calvin, en 19 år gammel hypokonder, der er bange for sin egen skygge, møder hinanden. Calvin hjælper Skye med at fuldføre sin excentriske "træskoliste" over ting, hun skal nå, inden hun dør. Undervejs lærer han at konfrontere og overvinde sin egen frygt - blandet andet frygten for at forelske sig i den smukke, men tilsyneladende uopnåelige Izzy.
Hannah's eksmand tror, han skal dø. Hannahs mand er forelsket i hendes søster Barbara. Hannah's to andre søstre vil låne penge af hende til deres nye catering-firma. Hannah skal sørge for Thanksgiving-middag til hele familien. Hannah ville have det en hel del lettere uden søstre samt tidligere og nuværende mænd.
Norman Jewison har instrueret et af Hollywoods mest berømte filmpar, Doris Day og Rock Hudson, som en munter hustru og hendes hypokondriske mand i denne film, som var deres tredje og sidste sammen. Hudson er vanvittigt morsom som en besat hypokonder, der kommer til at overhøre sin læge tale om en patients nært forestående død. I den tro at det er ham selv, går Hudson og en ven (Tony Randall) i gang med at finde en ny mand til hans kone, som jo snart bliver enke. Randall er desværre ikke nogen stor hjælp, fordi det forestående tab får ham til at drikke. Day bliver foruroliget over sin mands opførsel, og det bliver endnu værre, da en gammel flamme (Clint Walker) dukker op i deres country club og Hudson opmuntrer ham til at gøre tilnærmelser til hende!
Romain Faubert is a 39 year old, single, medical photographer... and a raging hypochondriac. His doctor and only friend Dr. Dimitri Zvenka thinks he knows the cure for Romain: dating! But with the arrival of freedom fighter Anton Miroslav, everyone might get more then they bargained for...
Quinn, a neurotic man, is diagnosed with a harmless eye condition and soon after his life spirals out of control. He second-guesses his plans to propose to his longtime girlfriend, Devon, after his beautiful coworker, Kelsey, confesses that she has a crush on him. After a conversation with his best friend, Jameson, he clumsily tries to explain his doubts to Devon, but his possible proposal turns into a break-up. When Devon flees to Paris, he follows her in a last-ditch effort to win back "the one."
The sexual relationship between a successful woman and her brother, an introvert, hypochondriacal youth, who is also a pornophile.
Odile is a business executive looking for a new, bigger apartment. Her younger sister Camille has just completed her doctoral thesis in history and is a Paris tour guide. Simon is a regular on Camille's tours because he's attracted to her. Camille has fallen for Marc, and they begin an affair. Nicolas is also looking for an apartment, since he hopes to eventually have his family join him in Paris.
A gang of thieves plan to make their fortune by stealing a shipment of contraceptive pills from Finisham maternity hospital. They assume disguises and infiltrate the hospital, but everything doesn't go according to plan. The hypochondriac consultant Sir Bernard Cutting, Matron and the doctors and nurses at Finisham have a habit of getting in the way.
Young boxer Michel Maudet is sacked by his manager after a series of match defeats and is forced to look for a new job. He is engaged as secretary to a millionaire named Ferchaux who is in a hurry to flee the country when he discovers he has been implicated in a high-profile fraud.
A small town doctor mistakenly ingests an experimental drug made from the blood of vampire bats which transforms the kindly medic into a bloodthirsty monster.
Dr. Steven Bishop is taken to the hideout of Frank Dillon and his gang to treat the wounded Joe Madison. Joe's nurse sister Nora Madison is also taken. Dillon tells Bishop that if Joe dies, he will be killed, but Bishop knows he will be either way. Joe dies, but Nora and Steve conceal it from Dillon and send a plea for help in a prescription that Bishop writes in Latin.
When his best friend dies of a heart attack, Ray Macklin becomes a man obsessed with his own mortality. Convinced that all his aches and pains are an indication of his imminent death, Ray's life turns into a slapstick farce of health-crazed anxiety and hypochondria.
Donald's got the day off, and all he can think of is golf until it rains as soon as he sets foot outside. He takes it out on his nephews. When he's sitting around moping, they take revenge by playing off his hypochondria.
Saving Norman tells the story of a hypochondriac ex-ping pong player who missed the biggest tournament of his career because of a cold. Now years later he lives a hermetic existence with his parrot Norman. But, when Norman seems to be suffering from a case of bird narcolepsy he calls in pet psychic Belinda who soon realizes that in order to help Norman, she'll first have to help his owner.
Jim is afraid of everything. In order to face his fears, Jim will bring everything he is afraid of into his house. It doesn't quite work out as expected..
Rich 'Old Man' Bill Morton is a hypochondriac. After bringing new sugar pills to Bill Morton's house, his physician, Doctor Malcolm Scott suggested to Bill Morton's wife that adopting a child might help cure Mister Morton of his delusions. After overhearing their conversation, Bill Morton quickly invited the "Our Gang" members, (as they were at the front come to the door, offering to work and pay for a broken window pane, that had just occurred) to a lunch, in order to sour his wife's thoughts of adopting any children. Then, the unexpected occurs as Alfalfa's two twin little brothers, Tisket and Tasket got to Bill Morton's medications' table, they ate up a majority of them, leading Bill Morton to call his physician, Malcolm Scott back to his house, immediately! When, Doctor Malcolm Scott return to Bill Morton's house, he laughs at what he hears and then tells Bill Morton they are worthless sugar pills, teaching a lesson to Bill Morton he is not sick at all.
Tucked away in his castle, a hypochondriac inventor plays generous host to a revolving cast of wacky guests. But to pay off his mounting debts, he must sell either a powerful businessman or a rich gypsy on his latest creation: a laser skywriter.
A woman finds brief respite from the selfishness of her husband with a young doctor, and their mutual attraction is rekindled by a chance meeting at a concert.