Na segunda parte das aventuras de Beethoven, o nosso herói conhece Missy, a cadela São Bernardo dos seus sonhos. Mas infelizmente terá que separar-se dela por causa de Regina, a dona de Missy, uma mulher terrível que a usa como moeda de troca para resolver o seu divórcio. Missy, Beethoven e os seus cachorros voltarão a reunir-se? E Regina, terá aquilo que merece?

Magorium (Dustin Hoffman) é um incrível senhor de 243 anos de idade, dono da loja de brinquedos mais fantástica do mundo. Tudo lá é mágico e parece ter vida. A única condição que se pede aos freqüentadores é muito simples: precisa acreditar para ver. Quando o Sr. Magorium decide se aposentar e deixar a loja para a encantadora Molly (Natalie Portman), coisas estranhas começam a acontecer.

A veteran general, living poorly but honestly with his wife and his daughter, is visited by his future son-in-law who informs him that he is going to immigrate to Australia. On the same day, his cousin Apostolos pays him a visit as well and tells him that the government intending to honor him has decided to construct his statue and place it at the small square in front of his house.

Years ago, Grigoris was forced to sell four velvet armchairs to the junk dealer. After the death of his aunt, he was informed that her entire legacy, which was a box of jewelry, was hidden in one of those four armchairs. In the meantime, the armchairs had been sold to other people, and so a desperate quest for the right armchair begins, resulting in many and sometimes grotesque adventures.