Beethoven is back -- and this time, he has a whole brood with him now that he's met his canine match, Missy, and fathered a family. The only problem is that Missy's owner, Regina, wants to sell the puppies and tear the clan apart. It's up to Beethoven and the Newton kids to save the day and keep everyone together.

Gino, a drifter, begins an affair with inn-owner Giovanna as they plan to get rid of her older husband.