蜘蛛侠在经历了重重考验之后，成为了人人敬仰的正义英雄，抱得美人归。但是，光环下的他也有自己的心病：他曾放走了小偷导致最亲爱的叔叔被小偷杀死，帕克一直耿耿于怀。生活顺意的帕克开始变得目中无人，当他再次抓到那个小偷时，残忍地看着他从楼上摔下致死，过后才发现自己惩罚错了人，真凶是“沙人”。当帕克将“沙人”残忍杀死后，帕克心内的阴暗面渐渐在帕克的身体内占据了上风，蜘蛛侠最终演变成邪恶的“毒蜘蛛”！糟糕的是，帕克没有察觉到自身的变化，帕克最终如何摆脱自身的邪恶？

东京近郊有一栋阴森的凶宅，所有到访者均会离奇毙命或神秘失踪。当年房屋的主人佐伯刚雄狂性大发，酿成惨案。 时隔5年，德永一家搬迁至此，大学女生仁科理佳前来做义工，不幸皆卷入诅咒，参与事件调查的警员也没能幸免，更有因胆大好奇而误闯凶宅的女学生，也被咒怨的阴云深深笼罩。

年轻的学生妹惠，不仅人长的漂亮，还拥有这一身犀利的空手道功夫。这天惠同一群老朋友一行五人，共同到树林中散心。五人在树林中钓鱼，却发现了鱼身上有种奇怪的寄生虫，接着，他们在上厕所的时候，就遭遇了丧尸的攻击。被吓得魂飞魄散的年轻人发现了怪博士田中和他女儿的家，连忙跑进去避难。可是他们不知道，恐怖的寄生虫以及丧尸，正是田中的试验品。究竟寄生虫同丧尸之间有着何种联系？惠的空手道能够帮助朋友们逃脱么？

Based on Tommy Jaud's bestselling novel, this comedy focuses on a dispassionate clerk and his set-backs in life. 29-year-old Simon works in a phone shop, but his thoughts just circle around finding a new girl-friend after being left by his last one year ago. While his Croatian cleaner tries to procure him, his efforts to chat up women in clubs also fail. However, he finds the woman of his dreams (and mother of their future children) in his most hated coffee shop, although not having a clue how to win her heart...