Når en uventet fiende truer den globale sikkerheten, må Nick Fury - direktør for det internasjonale fredsbevarende byrået S.H.I.E.L.D. - finne ut hvem som kan redde verden fra randen av katastrofe. En dristig verdensomfattende rekruttering iverksettes.
Når S.H.I.E.L.D. blir angrepet dras Captain America inn i et nett av intriger som truer hele menneskeheten. Et komplott oppdages og sammen med Black Widow og The Falcon må Cap bekjempe fiendens mektigste våpen så langt – The Winter Soldier.
Captain America: The First Avenger tar for seg Marvel-universets startfase, hvor Steve Rogers melder seg som frivillig forsøkskanin til et eksperiment som forvandler ham til supersoldaten kjent som Captain America. Rogers slår seg sammen med Bucky Barnes og Peggy Carter for å gå til krig mot den onde HYDRA-organisasjonen, ledet av superskurken Red Skull.
Agent Coulson stops at a convenience store and deals with a coincidental robbery during his visit.
The realm of magic is being threatened by the realm of logic, so Carolinus, the green wizard decides to shield it for all time. Ommadon, the evil red wizard, stands in his way. Carolinus then calls for a quest that is to be led by a man named Peter Dickinson, who is the first man of both the realms of science and magic. It is Peter's job to defeat Ommadon.
In the days of King Henry IV, stalwart young Myles and his sister Meg have been raised as peasants, without any knowledge of who their father really was. But one day, they journey to Macworth Castle. There, Myles falls in love with Lady Anne Macworth, makes friends and enemies, and learns to be a knight.
An artist, Steve Rogers, is nearly murdered by spies, looking for his late father's national secrets. He is saved during surgery when a secret formula is injected into him; this serum not only heals him but also gives him fantastic strength and lightning reflexes. To help him solve the mystery behind his father’s murder and bring those guilty to justice, a government agency equips him with a special motorcycle loaded with gadgets and an indestructible shield. Now armed, he battles against the nation's enemies as the Sentinel of Liberty, Captain America.