秘密特工伊森(湯姆·克魯斯 Tom Cruise 飾)隱藏了真實身份,准備和女友安心生活。這時,他突然接到了上級的電話。超市接頭時,同僚向他傳達了新的任務命令。任務中,他和黑人老搭檔以及兩位女將琳賽(凱莉·羅素 飾)和珍(Maggie Q 飾)並肩作戰,在攻入某大廈尋找一個名叫「兔子腿」的證物時,不幸中了埋伏,結果琳賽當場陣亡。因為被控失職,伊森身心背負了巨大的痛苦,在跟上司鬧翻之後,他執著地追查著這起事故的起因,卻在死者遺留的秘密視頻中發現了一個驚天大秘密。為了給死者報仇,讓罪魁禍首伏法,伊森踏上了去往上海尋找關鍵證據的凶險旅途,結果卻落入了犯罪團夥首領歐文(菲利浦·西摩·霍夫曼 飾)的圈套,甚至女友也成了人質……
Hiller, a computer expert, was bribed by group of bank robbers to obtain details of the security system at a newly-built bank. Having obtained the information, he thought he'd seen the last of the robbers. But now they've traced him and his son to London. They hold the son hostage and force Hiller to decode the information about the alarm and then to take part in the robbery.