O Ζακ, ένας νεαρός με σύνδρομο Down που ονειρεύεται να γίνει παλαιστής, δραπετεύει από το ίδρυμα στο οποίο φιλοξενείται και ξεκινάει να βρει τη σχολή πάλης του ινδάλματός του. Κι ενώ η εθελόντρια του ιδρύματος Έλινορ βρίσκεται στα ίχνη του, ο Ζακ θα συναντήσει στο δρόμο του τον Τάιλερ, έναν μικροπαράνομο που προσπαθεί να ξεφύγει από τους απειλητικούς διώκτες του.

Ο Calvin Campbell είναι ένας πρώην επαγγελματίας παίκτης του μπέιζμπολ ο οποίος έχει αποσυρθεί πρόωρα λόγω έντονων κρίσεων πανικού . Παρ' όλο που ήταν ένα από τα μεγαλύτερα ταλέντα στο χώρο του αθλήματος, η άστατη ζωή του και οι καταχρήσεις το έχουν φέρει ένα βήμα πριν από την αυτοκαταστροφή μέχρι τη στιγμή που ένας νεαρός με σύνδρομο Down που εργάζεται στο τοπικό μπακάλικο, θα ξαναδώσει πνοή και ελπίδα στη ζωή του

Το Cafe de Flore είναι μια ερωτική ιστορία για ανθρώπους που τους χωρίζουν ο χρόνος και ο τόπος, αλλά συνδέονται με βαθείς και μυστηρίους τρόπους. Ατμοσφαιρικό, φανταστικό, τραγικό κι ελπιδοφόρο, η ταινία καταγράφει τις παράλληλες μοίρες της Ζακλίν, μιας νεαρής μητέρας με ένα γιο με ειδικές ανάγκες τη δεκαετία του ’60 στο Παρίσι, και του Αντουάν, ενός πρόσφατα χωρισμένου άντρα, και πολύ πετυχημένου Dj στο Μόντρεαλ του σήμερα. Αυτό που συνδέει τις δύο ιστορίες είναι η αγάπη- εμμονική, τραγική, νέα και διαχρονική αγάπη…

Martin Durnley is a young man with an infantilizing mother, resentful stepfather and an institutionalized brother with Down's syndrome. To cope, he retreats into an alternate child personality he calls Georgie. After being caught during a theft attempt at a department store, he befriends a female customer who is sympathetic to him, but his friendship soon turns into obsession.

Georges has Down syndrome, living at a mental-institution, Harry is a busy businessman, giving lectures for young aspiring salesmen. He is successful in his business life, but his social life is a disaster since his wife left him and took their two children with her. This weekend his children came by train to meet him, but Harry, working as always, forgot to pick them up. Neither his wife or his children want to see him again and he is driving around on the country roads, anguished and angry. He almost runs over Georges, on the run from the institution since everybody else went home with their parents except him, whose mother is dead. Harry tries to get rid of Georges but he won't leave his new friend. Eventually a special friendship forms between the two of them, a friendship which makes Harry a different person.

Στα τέλη της δεκαετίας του 1970, ένας διανοητικά ανάπηρος έφηβος εγκαταλείπεται στην τύχη του αλλά ένα gay ζευγάρι τον αναλαμβάνει για να γίνει η οικογένεια που ποτέ δεν είχε. Μόλις η αντισυμβατική διαβίωση αποκαλύπτεται από τις αρχές, οι άνδρες πρέπει να καταπολεμήσουν ένα προκατειλημμένο νομικό σύστημα για να υιοθετήσουν το παιδί που αγάπησαν σα να ήταν δικό τους.

Detective Robert has his own office, a trench coat, a Bogart hat and Downs syndrome. The only thing he is missing is a case. Then a lady comes to his rescue.

During a blizzard in 1964, Dr. David Henry delivers his son Paul with the help of nurse Caroline. But when Henry realizes his wife is also carrying a girl with Down syndrome, he hands the second child over to Caroline without his wife's knowledge. Henry's fateful decision yields grave consequences for his family over the next 20 years.

Dr. Matthew Clark is the head of a state institution for intellectually disabled children. Jean Hansen, a former music teacher anxious to give her life some meaning, joins the staff of the hospital. Jean, who tries to shelter the children with her love, suspiciously regards Dr. Clark's stern training methods. She becomes emotionally involved with 12-year-old Reuben Widdicombe, who has been abandoned by his divorced parents.

Alba has Down syndrome and was left in the hospital when she was born. Thirty families rejected her before the court decided to entrust her to Luca Trapanese, gay and Catholic.

A mother must protect her family on Christmas Day from a demented stranger who is hell bent on tearing them apart.

Astrid is a comedian who makes people laugh for a living; her husband Markus is her manager and the two of them work well together. They have a nine-year-old daughter and are expecting their second child. When they learn that their child will not be born healthy, they are at first optimistic that they will be able to meet this challenge – although they have no idea what awaits them. But the closer it gets to the due date, the more Astrid begins to worry about the future of her unborn child as well as that of her family and her career. After many discussions and arguments Astrid realises that the decision that will affect all their lives must be made by her alone. What complicates matters further is the fact that, as a successful entertainer, she is in the eye of the public and the media.

In the beginning of the 19th century, Johannes Elias Alder is born in a small village in the Austrian mountains. While growing up he is considered strange by the other villagers and discovers his love of music, especially rebuilding and playing the organ at the village church. After experiencing an "acoustic wonder", his eye color changes and he can hear even the most subtle sounds.

Jess is thrilled to be the surrogate for her best friend and his husband, but when a prenatal test comes back, it creates a moral dilemma that threatens their friendship.

jefftowne is a 1998 documentary shot and directed by Daniel Kraus and distributed by Troma Entertainment. It chronicles the life of Jeff Towne, a 40 year old Iowa City resident who suffers from Downs Syndrome, obesity, alcoholism, and circulation problems. Towne also enjoys pornography and lives with his 90-year-old adoptive grandmother.

A woman attempts to stop her daughter signing away her down syndrome grandson for adoption. Based on a true story.

Emma's daughter Kendall becomes engaged, but Emma is concerned as Kendall and her fiancé have Down Syndrome and Emma worries she's not ready to take this step.

A young man journeys through a bizarre land inhabited by mentally impaired people, demons, and snails.

Dafne has recently lost her mother – and Luigi his wife – in an accident. But whilst this 30-year-old, who was born with Down’s syndrome, is still managing to master her life with verve after the terrible disaster, her father sinks into a depression. It will take all the energy Dafne can muster to help him get back on his feet. Fortunately, headstrong Dafne happens to have a lot of it up her sleeve.

After losing his mother, a boy with Down syndrome takes his trunk of magical costumes to live with his grandparents in this animated tale.