I 1986 blev Tommaso Buscetta den første højtstående mafiaboss nogensinde til at vidne mod mafiaen. Det kostede ham og hans familie alt.
Matt Weston er en nyuddannet CIA-agent, der vogter over et såkaldt "Safe House" i Sydafrika, da Tobin Frost, CIA’s mest eftersøgte overløber tages til fange og anbringes i Westons varetægt.
Cross er en gammel mand hos CIA, som ofte slår sig sammen med franskmanden Jean "Skorpion" Laurier, en talentfuld freelance-medarbejder. Efter deres sidste mission sammen, beordrer CIA Skorpionen til at eliminere Cross, hvilket efterlader ham intet andet valg end at adlyde.
Mace (Jessica Chastain) er hemmelig agent på en super vigtig opgave. Hun skal have fat i en topmoderne "dims", der gør det muligt at hacke ind i et hvilket som helst computersystem i verden. Alt fra bankkontorer til atomforsvaret er mulige mål. Desværre går alt ikke efter planen. Mace får ikke løst sin opgave, men den fiasko vil hun ikke have siddende på sig. Hun får rekrutteret et team af seje kvindelige agenter - alt fra en gammel ven til en tysk konkurrerende agent - så de sammen kan få fat i "dimsen" og redde verden!
A counter-terrorism expert takes a job protecting a young heiress. After an attempted kidnapping puts both of their lives in danger, they must flee.
Naomi, an Israeli Mossad agent, is sent to Germany to protect Mona, a Lebanese informant recovering from plastic surgery to assume her new identity. Together for two weeks in a quiet apartment in Hamburg, the relationship that develops between the two women is soon exposed to the threat of terror that is engulfing the world today. In this game of deception, beliefs are questioned, choices are made, and their fate takes a surprising turn.
Mercenary John Seeger is one of the best in the business. John and his crew battle some soldiers on Galmoral Island in Southern Africa as they're trying to rescue the French Ambassador -- there's a coup going on. Some of John's soldiers unload their machine guns into the Ambassador and his family, blowing the mission and getting his best friend Radio Jones killed. He heads back to the US and visits Radio's wife Shondra to tells her the news, and then promises that he'll take care of her and her son Eddie. But shortly after he makes that vow, Shondra and Eddie get kidnapped.
