Jerry runs into the Metropolitan Opera, trying to evade Tom.
Tom chases Jerry around a high-rise apartment, and then around the ledge surrounding the building. They torment each other with a compressed air horn. Jerry goes down a drainpipe and Tom follows, stretching himself the length of the pipe (and getting unstuck with help from the air horn).
Spike the bulldog, grateful to Jerry for getting him out of the dogcatcher's van, offers to help the little mouse any time he whistles. Tom, Jerry's feline tormentor, seeks to overcome this new disadvantage.
Tom and Jerry need to repeatedly come to the rescue when a teenage babysitter, supposed to be looking after the baby, is more interested in talking on the telephone than in paying attention to the baby who keeps crawling away.
Spike has just put Tyke to bed for his nap when Tom and Jerry chase out the door to Tyke's crib, waking him up. This gives Tyke an attack of hiccups. Spike warns Tom not to wake him up again, which of course is all Jerry needs.
Jerry uses a robot mouse to snatch a sample from a lunar cheese mine being mined by robots; Tom gives chase with a robot cat.
Jerry narrates in voiceover: Tom has fallen hard for the cat next door, and competes with rich cat Butch for her affections. But Butch outspends Tom to a ludicrous level at every turn. Tom goes downhill after that, until we see him contemplating suicide.
Spike is showing his son Tyke how to barbecue when his cooking is disrupted by a typical Tom-and-Jerry chase.
Tom, famous baritone Signor Thomasino Catti-Cazzaza, enthralls a concert audience with his rendition of "Largo al factotum", from Rossini's "Il Barbiere di Siviglia", while Jerry strives for sleep under the stage.
A dancing bear escapes from the zoo and finds his way to Tom and Jerry's house. He dances with Tom, making it impossible for Tom to call the authorities; Jerry takes every opportunity to play music and keep Tom and the bear dancing
Jerry and Tuffy lead the quest to thanksgiving. All the sudden, Tom sneaks into the dinning room to destroy Jerry and Tuffy. So, Jerry, Tuffy and Tom battle over thanksgiving. In the end, Jerry, Tuffy and Tom would agree to eat the whole turkey but Tuffy decides to ate the whole turkey.
An alley cat is foraging for food when he sees Tom's house and decides it's a rich haul. He dresses as a foundling baby and lands on the doorstep. Tom takes him in and Butch proceeds to raid the fridge between Tom's babying him. What he doesn't know is that Jerry's going to grab the ham Butch swiped every chance he gets.
Tom is in a pool hall after hours; as he soon discovers, Jerry is sleeping in the corner pocket. Tom chases Jerry around the table and the rest of the pool hall. Tom's energetic game of pool is more than Jerry can cope with. Soon, the table becomes a battlefield.
Tom and Jerry are in a bowling alley. Both spend a lot of time sliding on the well-polished lanes. Eventually, Jerry takes up residence among the pins and Tom tries to bowl him down.
Tom chases Jerry into a fish cannery; they get sealed into cans. Tom breaks out, but falls off a pier as the cans roll under him. A shark chases him out of the water; Tom drops an anchor on the shark. Meanwhile, Jerry has been hopping in his can; Tom opens it, and puts his finger in, which Jerry bites. Jerry tricks Tom into falling off the end of another pier, and right into the shark's path again. The shark manages to get Tom into a very precarious position, barely holding the jaws apart. Jerry takes pity, and dumps a shaker full of pepper into the shark, which ends up on the processing line and stuffed into a huge can. Tom is unrepentant, so Jerry tricks him with a fake shark fin.
Tom heads for a big city penthouse to become acquainted with a rich pretty female cat that lives there. He brings her Jerry as a gift and does some humiliating things to Jerry. Jerry, in turn, attracts the attention of another cat who also becomes interested in the female cat. It eventually turns into a fight between Tom and the other cat for the lady's hand but Jerry is the one who gets her in the end.
On a snowy night in the city, Jerry is comfortably asleep in his hole inside a penthouse, while Tom tries to keep from freezing to death in the alley below.
Tom fights with another cat over Jerry.
Tom joins his owner on a hunting safari in Kenya. Jerry has hidden himself in the Clint's luggage, and Tom quickly sees him and attempts to get rid of him.
Tom and Jerry are on a building construction site. Things explode, Tom loses his fur for a while, Jerry hides in a glove, Tom falls from a great height, and Tom has great trouble with a rock-and-girder see-saw.