25 år efter at en række brutale drab chokerede den lille by Woodsboro, er en ny morder på spil. Iført den ikoniske Ghostface-maske har personen udset sig en ny gruppe unge for at genoplive fortidens blodige hemmeligheder. Til undsætning kommer tre rutinerede kræfter, som har været oppe imod Ghostface af fire omgange før: Den evige overlever Sidney Prescott, betjenten Dewey Riley og journalisten Gale Weathers.

Vlogger Keith Gill sinks his life savings into GameStop stock and posts about it. When social media starts blowing up, so do his life and the lives of everyone following him. As a stock tip becomes a movement, everyone gets rich—until the billionaires fight back, and both sides find their worlds turned upside down.

A man wakes up in a mysterious chamber, there's some doctors claiming that they're about to perform a "standard procedure".