Charlotte is a woman with anger management issues whose therapist suggests she write a journal to keep her emotions in check. Unlucky in love, she ventures online to find a boyfriend. Just as she reaches her limit of unsuccessful dates, Charlotte meets her soul mate Lyle. Everything is perfect until Lyle finds Charlotte's journal and sets out to prove just how deeply he loves her.

After getting dumped for the 11th time in a row, Frankie discovers that she has a "loser in love" gene, which predisposes her to chronic failure and rejection for the rest of her life. She decides to embark on a quest to change her romantic future.