After the passing of his wife, a lonely newspaper editor discovers Berenalin: a medication that promises to put an end to his grief. Its effects begin to drive a wedge between him and his daughter, who needs him more than ever.

In New York City, Thom is broke and jobless, illegally working as a taxi driver. Claire is a successful business-woman, but personally she's in shambles - then comes the phone call that her estranged father is in the hospital. Not knowing what to do, Claire hops in Thom's cab and orders him to just drive and so he does. They find themselves in Pennsylvania and Claire makes the rash decision to drive across the country to California. On the road, there are many detours as the obstacles and secrets force them to learn about themselves and each other.

After three years in prison, Nader is given a furlough to go home. He has 48 hours to become a father to his four-year-old daughter.