For Dan Gallagher, life is good. He is on the rise at his New York law firm, is happily married to his wife, Beth, and has a loving daughter. But, after a casual fling with a sultry book editor named Alex, everything changes. Jilted by Dan, Alex becomes unstable, her behavior escalating from aggressive pursuit to obsessive stalking. Dan realizes that his main problem is not hiding his affair, but rather saving himself and his family.

After one short blind date, Mary Horowitz, a brilliant and eccentric crossword constructor, is convinced that Steve, a CCN cameraman, is her soul mate. Because his job takes him hither and yon, she crisscrosses the country following Steve, with the encouragement of a reporter, turning up at media events he's at to convince him they are perfect for each other. Along the way, she befriends an assortment of misfits who accept her for who she is, leading her to reassess her reasons for this strange journey.

住在洛杉磯的四個好朋友之中，有三人已婚，一人單身。當她們結伴參加一場又一場活動後，經濟差異也開始對四人的關係造成影響。