Forfatterspiren, Jack, og hans familie passer et elegant, men mørkt hotell over vinteren. Kort tid etter at de ankommer begynner hotellet å utøve sin ondskapsfulle kraft.

In order to save his dying father, young stunt cyclist Johnny Blaze sells his soul to Mephistopheles and sadly parts from the pure-hearted Roxanne Simpson, the love of his life. Years later, Johnny's path crosses again with Roxanne, now a go-getting reporter, and also with Mephistopheles, who offers to release Johnny's soul if Johnny becomes the fabled, fiery 'Ghost Rider'.

By the year 2056, an epidemic of organ failures has devastated the planet. The megacorporation GeneCo provides organ transplants on a payment plan - and those who can’t fulfill their plans have their organs repossessed. In the midst of this, a sickly teenager discovers a shocking secret about herself, her father, and their connection to GeneCo.

A doctor in early 19th-century Germany becomes infatuated with the sister of a man he unintentionally killed and bargains with the Devil incarnate to conjure their union in exchange for his soul.

An evil record tycoon is haunted and taunted by the disfigured composer Winslow Leach, whom he once wronged.

An orphaned young girl conjures an executed soldier back from the dead, and together they deliver hell in the Blackfoot territory of the late-1800s.