During a stopover in Germany in the middle of a carefree road trip through Europe, two American girls find themselves alone at night when their car breaks down in the woods. Searching for help at a nearby villa, they are wooed into the clutches of a deranged retired surgeon who explains his mad scientific vision to his captives' utter horror. They are to be the subjects of his sick lifetime fantasy: to be the first to connect people, one to the next, and in doing so bring to life "the human centipede."

A bigoted junkie cop suffering from borderline personality disorder and drug addiction manipulates and hallucinates his way through the festive season in a bid to secure promotion and win back his wife and daughter.

Bertram Pincus, a cranky, people-hating Manhattan dentist, develops the unwelcome ability to see dead people. Really annoying dead people. Even worse, they all want something from him, particularly Frank Herlihy, a smooth-talking ghost, who pesters him into a romantic scheme involving his widow Gwen. They are soon entangled in a hilarious predicament between the now and the hereafter!