I'm A Virgo är en fantastisk bli vuxen-resa som handlar om Cootie, en fyra meter lång ung svart man som bor i Oakland, Kalifornien. Cootie som vuxit upp gömd, upplever världen för första gången. Han skapar vänskapsband, hittar kärleken, navigerar pinsamma situationer och träffar sin idol, en äkta superhjälte vid namn Hjälten.

Yoshihito, a 23-year-old man who has no job or girlfriend. In order to make ends meet he rents out one of the rooms in his house. While he's showing Lily, his first tenant, around the house, she's suddenly attacked by a vampire named Vivian, and Yoshihito notices that Lily is actually a werewolf. As Yoshihito and Lily start living in the same house, Yoshihito is scouted for an organization that maintains order of the parallel universes, and strange creatures one after another become tenants in his house.

Daisū is a a manga creator who grew up in an orphanage, and whose works do not sell very well. Daisū lives each lonely day in boredom, but one day he meets a young man named Myō who has cat ears, and his everyday life completely changes. Myō gets in trouble every day, but for the first time in his life, Daisū’s heart experiences "warmth."