Jerri Blank is a former prostitute and junkie whore who returns to high school as a 46-year-old freshman at Flatpoint High. Jerri ran away from home and became 'a boozer, a user, and a loser' after dropping out as a teenager, supporting her drug habits through prostitution, stripping, and larceny. She has been to prison several times, the last time because she 'stole the TV'.
At home, Jerri's father Guy is comatose, although he seems perfectly capable of amazing feats. Her stepmother Sara is vain and bitter, and stepbrother Derrick is a bullying jock. Jerri tries to do things the right way but always ends up learning the wrong lesson. Her hijinks often involve, either directly or indirectly, neurotic history teacher Chuck Noblet and his secret lover, sensitive art teacher Geoffrey Jellineck.
終極一班這群吵吵鬧鬧，擁有特殊能力，高超戰技和時髦髮型的學生們，面對友誼的種種考驗，同時在高中生涯譜出浪漫戀曲。
故事設定在虛構的城市－王苦市，平凡人桃井陣於一次跑步時目擊一顆巨型桃子從天上降下，其後他走到該巨型桃子面前卻發現內有一個嬰兒。
21年後，剛獲得人氣的女高中生漫畫家鬼頭遙於一次使用手機時其手機則遭到神秘程式入侵，並且獲得一副神秘的墨鏡，而遙亦透過該墨鏡能夠看到超乎現實的實境以及偽裝為人類的神秘怪人。正當遙被這些神秘怪人圍毆時卻變身為鬼Sister與他們戰鬥，但隨後遙卻被誣陷抄襲他人漫畫，其作品亦因而被迫下架。
其後遙被帶到一處虛構空間內，並且與被囚禁在內的陣會面，而陣亦指示遙「去找尋桃井太郎並向其宣誓效忠！」，而最後與其多次相遇的任職快遞的信緣熱血青年就是遙所尋找的桃井太郎／Don桃太郎，而其他作為太郎的侍從還有無職的風流人猿原真一／猿Brother、被誣陷有罪的逃亡者犬塚翼／犬Brother以及平凡的已婚男性上班族雉野剛／雉Brother。
來栖一騎和諏訪零是一對殺手搭檔，某天突然陷入要照顧一位四歲女孩的窘境，而這女孩的出身竟是被兩人所解決的極惡黑手黨的私生子…
三年前稻葉夕士因為父母雙亡，搬到伯父家，接受伯父一家的照顧，原本希望在考上高中後就搬進宿舍開始獨立生活……沒想到宿舍竟慘遭火災肆虐而付之一炬！費盡千辛萬苦的夕士在因緣際會之下搬進了房租便宜、附伙食還附溫泉的超好康公寓——壽莊。但是，那裏居然是有妖怪出沒的「妖怪公寓」，夕士「普通」的高中生活就此展開。
The DarkZide stealthily appeared on Earth from their dying world in Dark Dimension to acquire the Larmu, human life-energy, to continue their existence. To counter the threat, Takeshi Munakata of the Cabinet Secret Service established the group S.A.I.D.O.C to intercept the DarkZide. S.A.I.D.O.C developed the Crystal Power needed to completed the Changérion project. However, the power was accidentally transferred into the body of detective Akira Suzumura.
John Kricfalusi, the creator of the original Ren & Stimpy Show, is back at the helm with new adventures of Ren Höek and Stimpson J. Cat (Stimpy) in Ren & Stimpy Adult Party Cartoon, with the emphasis toward adults instead of children. These half-hour long episodes feature the duo in new situations. The original humor that made Ren & Stimpy a success is back, like flatulence jokes and gross-out gags, combined now with adult themes and situations.