A hotel room in the center of Rome serves as the setting for Alba and Natasha, two sexy and recently acquainted women, to have a physical adventure that touches their very souls.
For Dan Gallagher, life is good. He is on the rise at his New York law firm, is happily married to his wife, Beth, and has a loving daughter. But, after a casual fling with a sultry book editor named Alex, everything changes. Jilted by Dan, Alex becomes unstable, her behavior escalating from aggressive pursuit to obsessive stalking. Dan realizes that his main problem is not hiding his affair, but rather saving himself and his family.
When Sarah Marshall dumps aspiring musician Peter Bretter for rock star Aldous Snow, Peter's world comes crashing down. His best friend suggests that Peter should get away from everything and to fly off to Hawaii to escape all his problems. After arriving in Hawaii and meeting the beautiful Rachel Jansen, Peter is shocked to see not only Aldous Snow in Hawaii, but also Sarah Marshall.
New York City is full of lonely hearts seeking the right match, and what Alice, Robin, Lucy, Meg, Tom and David all have in common is the need to learn how to be single in a world filled with ever-evolving definitions of love.
Having thought that monogamy was never possible, a commitment-phobic career woman may have to face her fears when she meets a good guy.
Cursed since childhood, dentist Charlie Logan cannot find the right woman. Even worse, he learns that each of his ex-girlfriends finds true love with the man she meets after her relationship with him ends. Hearing of Charlie's reputation as a good-luck charm, women from all over line up for a quick tryst. But when Charlie meets the woman of his dreams, he must find a way to break the curse or risk losing her to the next man she meets.
After witnessing a mysterious woman brutally slay a homemaker, prostitute Liz Blake finds herself trapped in a dangerous situation. While the police thinks she is the murderer, the real killer is intent on silencing her only witness.
A slacker and a career-driven woman accidentally conceive a child after a one-night stand. As they try to make the relationship work, they must navigate the challenges of parenthood and their differences in lifestyle and maturity.
Challenges of impending parenthood turn the lives of five couples upside down. Two celebrities are unprepared for the surprise demands of pregnancy; hormones wreak havoc on a baby-crazy author, while her husband tries not to be outdone by his father, who's expecting twins with his young trophy wife; a photographer's husband isn't sure about his wife's adoption plans; a one-time hook-up results in a surprise pregnancy for rival food-truck owners.
Tom and Hannah have been platonic friends for 10 years. He's a serial dater, while she wants marriage but hasn't found Mr. Right. Just as Tom is starting to think that he is relationship material after all, Hannah gets engaged. When she asks Tom to be her 'maid' of honor, he reluctantly agrees just so he can attempt to stop the wedding and woo her.
College buddies chip in and promise that the group's last unmarried man will collect a cash pot. Seven years later, the kitty is worth $500,000 -- money Michael needs to pay a gambling debt. Problem is, the only other single guy is a hopeless womanizer!
Four pals are stuck in a rut in adulthood: Adam has just been dumped, Lou is a hopeless party animal, Craig is a henpecked husband, and Jacob does nothing but play video games in his basement. But they get a chance to brighten their future by changing their past after a night of heavy drinking in a ski-resort hot tub results in their waking up in 1986.
After an extremely regrettable one night stand, two strangers wake up to find themselves snowed in after sleeping through a blizzard that put all of Manhattan on ice. They're now trapped together in a tiny apartment, forced to get to know each other way more than any one night stand should.
A small town waitress gets a nail accidentally lodged in her head causing unpredictable behavior that leads her to Washington, DC. Sparks fly when she meets a clueless young senator who takes up her cause - but what happens when love interferes with what you stand for?
Though Rachel is a successful attorney and a loyal, generous friend, she is still single. After one drink too many at her 30th-birthday celebration, Rachel unexpectedly falls into bed with her longtime crush, Dex -- who happens to be engaged to her best friend, Darcy. Ramifications of the liaison threaten to destroy the women's lifelong friendship, while Ethan, Rachel's confidant, harbors a potentially explosive secret of his own.
When Dustin's girlfriend, Alexis, breaks up with him, he employs his best buddy, Tank, to take her out on the worst rebound date imaginable in the hopes that it will send her running back into his arms. But when Tank begins to really fall for Alexis, he finds himself in an impossible position.
Hopeless romantic Stensland thinks he's found true love with an older woman, Morgan, only to learn that she's married and that their fling is merely an instrument of revenge against her neglectful husband, Grady. Initially out for blood, Grady finds himself strangely sympathetic to Stensland's plight and decides to get revenge on his wife instead.
Cooper is an actor who sees life as one big party, while Ed is in advertising and takes life too seriously. When Ed gets stressed over a deadline he has to meet, his brother Cooper works hard in trying to get his brother hooked up with a girl, thus a long weekend of stress and beautiful women, culminating in Ed meeting, and making love to, the woman of his dreams.
Ayumi Nitta is a member of a hospital cleaning staff and suffers from extreme social anxiety. After having a one-night stand with genius surgeon and sex addict Wataru Makino, Ayumi discovers she’s pregnant. However, when she tells Wataru, he dismisses her claim as a bad April Fools joke. Refusing to believe he could possibly be the father of Ayumi’s baby after just one night together, Wataru takes a woman named Reiko on a date to an Italian restaurant. However, Ayumi also shows up, leading to a major incident.
After being drugged and raped at a party, a young woman contracts what she thinks is an STD, but it's actually something much worse.