เรื่องราวของสองศรีพี่น้องตระกูลแดชวูด เอลินอร์ผู้ยึดมั่นในเหตุผล และแมริแอนน์ผู้ยึดมั่นในความรัก แต่โอกาสที่จะได้แต่งงานของเธอต้องพังครืนลง เมื่อฐานะทางการเงินของครอบครัวเริ่มง่อนแง่น
After returning from a year-long Moon mission, Cassie, a NASA botanist, finds herself in a remote cabin in the woods, where her estranged twin sister, Stella, a former NASA architect, has found a new life with climate activist Bryan. Old wounds resurface as the sisters attempt to pick up the pieces of the rivalry that broke them apart.
The vaudeville act of Harriet and Queenie Mahoney comes to Broadway, where their friend Eddie Kerns needs them for his number in one of Francis Zanfield's shows. When Eddie meets Queenie, he soon falls in love with her—but she is already being courted by Jock Warriner, a member of New York high society. Queenie eventually recognizes that, to Jock, she is nothing more than a toy, and that Eddie is in love with her.
A good nurse ruins her career by covering up for her sister's careless mistake.
The three siblings Eva, Lieke and Maarten are going through a rough patch. Eva has cancer, but she doesn't want the rest of the family to know. She only confides in young Luke, a cancer patient in the same hospital. Her brother Maarten also has a secret: although he is married to Sanne, he has fallen in love with his friend Hugo and doesn't quite know how to deal with it. In Lieke's case, it is her father Ferry who is causing stress. Because he is not at all happy about his daughter's choice of partner.