The Dashwood sisters, sensible Elinor and passionate Marianne, whose chances at marriage seem doomed by their family's sudden loss of fortune. When Henry Dashwood dies unexpectedly, his estate must pass on by law to his son from his first marriage, John and wife Fanny. But these circumstances leave Mr. Dashwood's current wife, and daughters Elinor, Marianne and Margaret, without a home and with barely enough money to live on. As Elinor and Marianne struggle to find romantic fulfillment in a society obsessed with financial and social status, they must learn to mix sense with sensibility in their dealings with both money and men.

The vaudeville act of Harriet and Queenie Mahoney comes to Broadway, where their friend Eddie Kerns needs them for his number in one of Francis Zanfield's shows. When Eddie meets Queenie, he soon falls in love with her—but she is already being courted by Jock Warriner, a member of New York high society. Queenie eventually recognizes that, to Jock, she is nothing more than a toy, and that Eddie is in love with her.

A good nurse ruins her career by covering up for her sister's careless mistake.

After returning from a year-long Moon mission, Cassie, a NASA botanist, finds herself in a remote cabin in the woods, where her estranged twin sister, Stella, a former NASA architect, has found a new life with climate activist Bryan. Old wounds resurface as the sisters attempt to pick up the pieces of the rivalry that broke them apart.

The three siblings Eva, Lieke and Maarten are going through a rough patch. Eva has cancer, but she doesn't want the rest of the family to know. She only confides in young Luke, a cancer patient in the same hospital. Her brother Maarten also has a secret: although he is married to Sanne, he has fallen in love with his friend Hugo and doesn't quite know how to deal with it. In Lieke's case, it is her father Ferry who is causing stress. Because he is not at all happy about his daughter's choice of partner.