Akcja filmu toczy się w Peru pod koniec XIX wieku. W miasteczku Iquitos pojawia się Brian Sweeney Fitzgerald z Irlandii. Przez tubylców zostaje okrzyknięty jako Fitzcarraldo. Jego marzeniem jest stworzenie europejskiej opery w amazońskiej dżungli. Aby je zrealizować, postanawia dołączyć do właścicieli kauczuku i wyrusza statkiem na podróż po Dżungli Amazońskiej.

In the early 1800s, a group of fur trappers and Indian traders are returning with their goods to civilization and are making a desperate attempt to beat the oncoming winter. When guide Zachary Bass is injured in a bear attack, they decide he's a goner and leave him behind to die. When he recovers instead, he swears revenge on them and tracks them and their paranoiac expedition leader down.

In April 1918, a disease of unknown origin swept across the five continents. In 18 months, millions of lives that had not been taken by the war were swept away by a virus that would cause the worst pandemic in history: the Spanish flu.