Pennsylvania, 1956. Frank Sheeran, a war veteran of Irish origin who works as a truck driver, accidentally meets mobster Russell Bufalino. Once Frank becomes his trusted man, Bufalino sends him to Chicago with the task of helping Jimmy Hoffa, a powerful union leader related to organized crime, with whom Frank will maintain a close friendship for nearly twenty years.

A gang of thugs devise a cruel hoax that goes horribly wrong as Melvin, a nerdy emaciated janitor at the local health club, is cast through a third story window into a vat of hazardous toxic waste.

Genial shopkeeper Philip has to endure the constant nagging of a shrewish wife while he secretly yearns for a pretty young stenographer. When the henpecking gets to be too much, Philip murders his wife and manages to make her death look like an accident. A ruthless blackmailer and a low-key detective both discover Philip's secret, and he has to decide which of them poses the more dangerous threat.

As a child, the brutal murder of her family made Alexis regain her hearing along with synesthetic abilities. Now as an adult, she finds solace in the sounds of bodily harm. But when she’s told she might lose her hearing again, she escalates her gruesome sound experiments in a quest to compose her masterpiece.

Leo Zimmermann, a business man from Paris dotes on his daughter. He proposes a strange offer to his killer when he is in town to execute Zimmermann.