Frank Sheeran er en hustler og lejemorder, som arbejdede sammen med nogle af de mest berygtede personer i det 20. århundrede. Over flere årtier fortælles historien om et af de største uløste mysterier i amerikansk historie, nemlig forsvindingen af den legendariske fagforeningschef Jimmy Hoffa. Filmen viser den storslåede rejse gennem den organiserede kriminalitets indre systemer, stridigheder og politiske forbindelser.

Den slatne gulvvasker Melvin bliver tvunget ud af et vindue og falder ned i en tønde med kemikalier. Disse forvandler ham på mirakuløs vis til The Toxic Avenger, Tromavilles beskytter! Nu har skurkene noget at bekymre sig for.

Genial shopkeeper Philip has to endure the constant nagging of a shrewish wife while he secretly yearns for a pretty young stenographer. When the henpecking gets to be too much, Philip murders his wife and manages to make her death look like an accident. A ruthless blackmailer and a low-key detective both discover Philip's secret, and he has to decide which of them poses the more dangerous threat.

As a child, the brutal murder of her family made Alexis regain her hearing along with synesthetic abilities. Now as an adult, she finds solace in the sounds of bodily harm. But when she’s told she might lose her hearing again, she escalates her gruesome sound experiments in a quest to compose her masterpiece.

Leo Zimmermann, a business man from Paris dotes on his daughter. He proposes a strange offer to his killer when he is in town to execute Zimmermann.