Шерлок Холмс детектив је у Лондону. Холмсов помоћник је др Џон Вотсон који се вратио из војне службе у Авганистану где је радио као љекар. Иако инспектор Лестрад у почетку сумња у Холмса као и остатак његовог тима, Холмсова их интелигенција и моћи запажања убрзо увере да је Вотсон важан у решавању разних случајева. Док решава случајеве, његов највећи непријатељ, Моријарити, кује му подли план и завршни проблем.

Sherlock Holmes uses his abilities to take on cases by private clients and those that the Scotland Yard are unable to solve, along with his friend Dr. Watson.

Loosely based on the "Sherlock Holmes" series by Sir Arthur Conan Doyle, Sherlock Hound turns all the classic characters into dogs. The canine Sherlock Holmes, his assistant Watson, and housemaid Mrs. Hudson work together to solve mysteries. The culprit is usually Professor Moriarty and his gang, who use all kinds of wacky contraptions to steal what they want.

The first American television series of Sherlock Holmes adventures aired in syndication in the fall of 1954. The 39 half-hour mostly original stories were produced by Sheldon Reynolds and filmed in France by Guild Films, starring Ronald Howard as Holmes and Howard Marion Crawford as Watson. Archie Duncan appeared in many episodes as Inspector Lestrade. Richard Larke, billed as Kenneth Richards, played Sgt. Wilkins in about fifteen episodes. The series' associate producer, Nicole Milinaire, was one of the first women to attain a senior production role in a television series.

Sherlock Holmes is a series of Sherlock Holmes adaptations produced by British television company BBC between 1965 and 1968. This was the second screen adaption of Sherlock Holmes for BBC Television.