Out of the blue, monsters usually living beneath the Earth’s surface began to attack the terrestrial world. They were called the Underground Hades Empire Infershia. The Ozuki Siblings of Makito, Houka, Urara, Tsubasa, and Kai hear from their mother, Miyuki, that they are the Magicians of Justice to stand against the Infershia. The siblings are perplexed by such an unexpected event. However, without hesitation, Miyuki charges at the Infershia, and the Ozu Siblings are forced to come together to fight as one.

Twenty years after their planet was attacked by the brutal Zone Empire, the five Hoshikawa children, who escaped and were raised on Earth, must prepare for a brand-new war. This time, though, they're ready ... having developed the powerful Fiveman technology that will help them defend Earth from the same empire that conquered their home world.

Grandiene has been waiting for the day of resurrection, the day when the planets are in the alignment of the Grand Cross. Her children descend to the Earth to make it a realm of darkness for her. Ten years prior, Doctor Tatsumi of the Tatsumi Disaster Prevention Institute predicted this event, but nobody believed him. He left his family so he could secretly develop and construct the Rescue System. Now in 1999, Doctor Tatsumi appears again to give the means to save the world to his children as the GoGoFive team.

A group of children and adolescents with supernatural abilities pose as a family to hide their powers from a volatile military man who seeks to use them for nefarious deeds.