這部寫實風格的黑幫劇情影集改編自真人真事，講述哥倫比亞惡名昭彰、行事殘暴，且勢力龐大的販毒集團的故事。

1980年代早期，毒販尚未集團化的戰國時期，一位想要一統江湖的野心實業家崛起，以過人的膽識與計謀建立帝國；另一方面，尚不成氣候的緝毒署，則出了一位熱血英雄，用他無盡的衝勁與勇氣，動搖腐敗的官僚體制，為現代的反毒戰士們鋪好了先驅之路。

Based on a true story and the book, At the Devil's Table: The Untold Story of the Insider Who Brought Down the Cali Cartel by award-winning investigative reporter William C. Rempel, En la Boca del Lobo follows the series of events that ultimately lead to the dramatic downfall of Colombia’s infamous Cali drug cartel. The story centers on Ricardo Salgado, an engineer and soldier who rises ranks and became in charge of the security of the godfather of the Cali Cartel, one of the largest criminal organizations in the world and rival of the Medellin Cartel.

In the 1980s, Liverpool became the epicentre of a drugs boom that was to change Britain forever. With unprecedented access to some of the biggest players, this is the story of how drugs went mainstream and dealing became a multi-billion pound business

(Ahmed) returns from abroad after obtaining a doctorate in philosophy, disappointing his father, who wanted him to study business administration to take over the management of the institution he owns, and marries Noura and his cousin Najwa, and is accused of killing the latter, so he escapes to Egypt and falls prey to a drug gang.