故事發生在第三季的9個月後，接二連三源自顛倒世界的離奇死亡事件引發霍金斯居民的恐慌。

1986年3月，來自顛倒世界的威可那連續殺害數名高中生，這使分道揚鑣的夥伴必須面對這場威脅。同時喬絲·拜爾斯和莫瑞·鮑曼試圖幫助被囚禁在俄羅斯堪察加半島監獄中的吉姆·哈普逃亡。本季的劇情共分為三個不同的視角敘述。

位於霍金斯的視角以達斯汀、麥克絲、艾瑞卡、史帝夫、南西、蘿蘋和路卡斯為主角。達斯汀和朋友們加入了龍與地下城社團「地獄火俱樂部」。團長艾迪親眼目睹籃球校隊隊長傑森的女友克莉希遭離奇殺害，卻成為頭號嫌疑人，並被傑森等人追趕，認為艾迪在撒旦的幫助下獲得殺死克莉希的力量。在連續數名青少年離奇死亡後。夥伴們意識到此次連環殺人事件的主謀是來自顛倒世界的強大生物威可那。

位於加州的視角，以搬至新家的11號、威爾、喬納森及前來探望的麥克為主角。由於霍金斯面臨新的威脅，11號被布倫納和歐文斯帶到一個秘密實驗室以恢復她的超能力，另一邊的麥克、威爾、喬納森和他的朋友阿蓋啟程尋找11號的下落。

以喬絲和莫瑞為主的視角，講述他們得知哈普倖存的消息，於是帶著贖金前去解救。而囚禁在俄國堪察加半島的哈普，要與被俄國人俘虜的魔神戰鬥。

Every summer, Belly and her family head to the Fishers’ beach house in Cousins. Every summer is the same ... until Belly turns sixteen. Relationships will be tested, painful truths will be revealed, and Belly will be forever changed. It’s a summer of first love, first heartbreak and growing up — it's the summer she turns pretty.

The story of what happens when five high schoolers walk into detention and only four make it out alive. Everyone is a suspect, and everyone has something to hide.

Prince Wilhelm adjusts to life at his prestigious new boarding school, Hillerska, but following his heart proves more challenging than anticipated.

Angsty and awkward fifteen year old Ginny Miller often feels more mature than her thirty year old mother, the irresistible and dynamic Georgia Miller. After years on the run, Georgia desperately wants to put down roots in picturesque New England and give her family something they've never had... a normal life. But it's not all carpool and Kombucha as Georgia's past threatens her and her family's new way of life... and Georgia will do anything to protect her family.

Six teenagers with different lives and personalities attend a prominent private school with only one thing in common: their vocation and passion for music.

The realistic chronicles of a working class group of Hispanic youth, with heavy subject matter like sex, drug dealing, teen pregnancy, abuse, drinking, rape, deception, and heartbreak.

The series accompanies a group of 16-year-olds on the journey of their life following their day to day in real time. Dependence on social media, how they face sex, love and ruptures, religion, the search of their identity and the need to fit in.

Head back to Elite Way School as a new generation of students hope to win the Battle of the Bands.

Skam France follows five french girls and their friends as they go to high-school.

Millennials experience first love and discover their emerging identities in this teen drama told partly through texts, chats and social media posts.

Rebellious Brooklyn teen Summer Torres is sent to live with family friends in the tiny town of Shorehaven on the Great Ocean Road, Victoria, AUS. Despite her best efforts, Summer falls in love with the town, the people and the surf.

A double-homicide in a small midwestern suburb rattles the lives of a group of teenagers and sends investigators searching for answers in the fall of 1995. A meditation on growing up, the passing of time, and the insidious violence that lurks in the suburbs.

SKAM Austin follows the lives of students at Bouldin High.

The school music club is on the verge of closure. In order for the club to continue to exist, the new club leader has to take a desperate step - to become a servant of the school president. How will this tangled story end?

Be My Boyfriend, a spin-off of the popular web series, Best Mistake, depicts the story of Lee Seung Min, a boy with zero presence who is offered a contract relationship by Oh Ji Na, the best girl-crush idol trainee in the school.

The story of a group of teenagers in high school in Utrecht, The Netherlands, in their search for friendship, love, their own identity, and overcoming fears.

A girl who lies the biggest lie of her life to protect her first love.

A boy who doesn't recognize her like that of her and waits for the day when she will become an idol of her own dream.

What is this unfamiliar feeling that rises between the two as they solve an unexpected crisis together?