"Mortal Kombat" er en mægtig kampsportskonkurrence som vil afgøre jordens skæbne. Menneskehedens tre repræsentanter, Liu Kang, Sonya Blade og Johnny Cage skal i en række kampe besejre den onde troldmand Shang Tung, og hans grusomme håndlangere Scorpio, Sub-Zero og det firearmede monster Prins Goro. Heltene får hjælp af tordenguden Lord Rayden.

Kenshi Takahashi, having reclaimed his clan's legendary sword Sento, is now on a mission to use his skills for good and aid the people of Earthrealm. Now as a member of the O.I.A. (Outworld Investigation Agency) he can do exactly that. When threats from other realms make their way to his own, Kenshi must enter fight against or ally alongside former adversaries to ensure Earthrealm's safety.