Mousie and Sad Girl are childhood best friends in a contemporary Los Angeles poor Hispanic neighborhood. But when Sad Girl becomes pregnant by Mousie's boyfriend, a drug dealer named Ernesto, the two become bitter enemies. While their dispute escalates towards violence, the violence of the world around them soon also impacts their lives.

An allergy-ridden, eavesdropping sound engineer and his boisterous new roommate are thrust into a missing girl case when he discovers clues to her disappearance in his neighborhood recordings.