The famous Borgia Pearl, a valuable gem with a history of bringing murder and misfortune to its owner since the days of the Borgias, is brought to London, thanks in part to Sherlock Holmes. But before long the jewel is stolen, due to an error on Holmes' part, and shortly thereafter, a series of horrible murders begin, the murderer leaving his victims with their spines snapped and surrounded by a mass of smashed china.

A facially disfigured and mentally unhinged man wreaks his revenge on those he blames for his condition.

An unsuccessful sculptor saves a madman named "The Creeper" from drowning. Seeing an opportunity for revenge, he tricks the psycho into murdering his critics.

Once again Paula the ape woman is brought back to life, this time by a mad doctor and his disfigured assistant, who also kidnaps a nurse in order to have a female blood donor.