Nerodni muzejski čuvaj Larry se vrača v fantastični svet oživelih zgodovinskih osebnosti, saj skuša rešiti stara prijatelja - kavboja Jedediaho in rimskega vojskovodjo Octaviusa, ki so ju po pomoti premestili v slavni muzej Smithsonian. Načrt se izjalovi, ko oživijo tudi ostale muzejske figure, od Napoleona, predsednika Lincolna, pustolovke Amelie Earhart, gangsterja Ala Capona in znanstvenika Alberta Einsteina, ki skupaj z Larryjevimi starimi znanci povzročijo popolno zmedo katastrofalno-komičnih razsežnosti.

Zia, distraught over breaking up with his girlfriend, decides to end it all. Unfortunately, he discovers that there is no real ending, only a run-down afterlife that is strikingly similar to his old one, just a bit worse. Discovering that his ex-girlfriend has also "offed" herself, he sets out on a road trip to find her.

The chance meeting of two people at the darkest moments of their lives leads to a bright new beginning : Arthur (around 50) and Claire (around 30) pull each other from the abyss – by trying to save the other they see the worth of their own life.

A year after the death of his paternal grandmother at the age of 101, filmmaker Martin Villeneuve brings her back to life using a special talent.