Nattevagten Larry er skal igen holde styr på hele museet, mens alle genstandene under en ombygning midlertidigt flyttes til verdens største museumskompleks 'The Smithsonian Institute'. Larry er den eneste der kender til den forbandelse, der gør at genstandene om natten bliver levende. Sammen med Roosevelt og piloten Emilia Erhardt forsøger han at undgå at flytningen ender i det totale kaos...

Zia, distraught over breaking up with his girlfriend, decides to end it all. Unfortunately, he discovers that there is no real ending, only a run-down afterlife that is strikingly similar to his old one, just a bit worse. Discovering that his ex-girlfriend has also "offed" herself, he sets out on a road trip to find her.

The chance meeting of two people at the darkest moments of their lives leads to a bright new beginning : Arthur (around 50) and Claire (around 30) pull each other from the abyss – by trying to save the other they see the worth of their own life.

A year after the death of his paternal grandmother at the age of 101, filmmaker Martin Villeneuve brings her back to life using a special talent.