Vowing to avenge the murder of his parents, Bruce Wayne devotes his life to wiping out crime in Gotham City as the masked vigilante "Batman".

The New Batman Adventures is a continuation of the acclaimed Batman: The Animated Series. Stories in this series tend to give more focus to Batman's supporting cast, which include fellow crimefighters Robin, Nightwing, and Batgirl, among others. The show also features guest stars such as Supergirl, Etrigan, and The Creeper; characters who would later appear with Batman in Justice League and Justice League Unlimited.

The series is set in New Gotham City, several years after it has been apparently abandoned by Batman. In his absence, Huntress, Oracle and Dinah are now the protectors of New Gotham: the Birds of Prey, and had taken over his war on crime. They are joined by Alfred Pennyworth, who serves Helena as she is heir to the Wayne estate; and Detective Jesse Reese, a police officer confronted with crimes and abilities he cannot explain.

A central feature of the series is the concept of metahumans: individuals born with powers that cannot be explained. No two metahumans have the same abilities (unless hereditary), and there exists a whole subculture of metahuman society that the outside world knows nothing about.

Set during Bruce Wayne's early years as the Batman, following his initial period of battling organized crime. He hones his skills with the assistance of his butler, Alfred Pennyworth. Bruce is introduced to Alfred's goddaughter, Tatsu Yamashiro. Tatsu is a martial arts swordsmaster hired to act as Bruce's bodyguard, but also recruited to act as a superhero partner to Batman.

As new villains overrun Gotham City of the future, the aging Bruce Wayne hangs up the cape of the once invincible Batman. But when troubled teenager Terry McGinnis stumbles upon the Dark Knight's secret, a new alliance is forged. And a triumphant new Batman is born.

A young billionaire Bruce Wayne fights crime and evil as the mysterious vigilante, The Batman.

In the aftermath of Bruce Wayne's murder, his rebellious adopted son forges an unlikely alliance with the children of Batman's enemies when they are all framed for killing the Caped Crusader.