前作で怒りのあまりに、一流殺し屋が集う「コンチネンタルホテル」の掟である「ホテル内で殺しはおこなってはいけない」を破ってしまったジョン。聖域から追放された彼を待っていたのは、組織による粛清の包囲網だった。刺客たちがさまざまな殺しのスキルを駆使し、賞金首となったジョンに襲いかかる。傷だらけとなったジョンは、かつて「血の契約」を交わしたソフィアに協力を求め、カサブランカへと飛ぶ。
Tomás, who lives in Canada, travels to Madrid, Spain, to visit his old friend Julián. Both of them, accompanied by Truman, Julián's faithful dog, will share many surprising and emotional little moments, triggered by the hard situation Julián is going through, for just a few days.
Dharma is stuck in a rut with his negative and lonely lifestyle and spends each day in the comfort of his loneliness. A pup named Charlie who is naughty and energetic which is a complete contrast with the Dharma’s character enters his life and gives him a new perspective towards it.
Ismael, widower of his beloved wife Teresa, walks the streets of the city in search of cardboard, in his extensive travels he has confrontations with Juan - a mental patient who thinks he is a dog and with Luigi - the most famous baker in the city. , who always scolds her daughter, because she did not inherit his gift in baking. But the destiny of these people is about to change, thanks to a magical event that Ismael will unleash.
The life of Zuzia, whose dad works on the railway, changes mas-sively when Lampo, an extraordinary travelling dog, joins the family. The remarkable shepherd dog, whose train trips are an internet sensation, immediately becomes the best friend of the girl suffering from a heart condition.
A man and his dog cross the desert in search of La Frontera, a mighty river that represents the geographical limit with the neighboring territory. Exhausted, they manage to see their goal, but they must cross other obstacles before conquering its waters.
David, a Jewish resistance fighter, flees for his life as he is being hunted by Nazi soldiers and is saved by a ferocious German Shepherd, who ultimately becomes his savior.
A documentary film about veterans with PTSD who find that, after other treatments fall short, a service dog helps them return to an independent feeling life.