When oil is discovered in 1920s Oklahoma under Osage Nation land, the Osage people are murdered one by one—until the FBI steps in to unravel the mystery.

悪名高きアウトローとして数々の犯罪に手を染め、法をあざけり、自分自身のルールで生きてきたジェシー・ジェームズ（ブラッド・ピット）。理想に燃える野心家の若者ロバート・フォード（ケイシー・アフレック）は、そんなジェシーの仲間になれたことを心から喜んでいたが、思わぬ事態が彼らを待ち受ける。

Buffalo Bill plans to put on his own Wild West sideshow, and Chief Sitting Bull has agreed to appear in it. However, Sitting Bull has his own hidden agenda, involving the President and General Custer.

A revisionist western, "Doc" is Frank Perry's attempt to accurately portray the lives and persons of Doc Holliday, Wyatt Earp, and the now-legendary events that took place in the town of Tombstone, starring Stacy Keach, Faye Dunaway and Harris Yulin.